Associations Between PM2.5 Components and Cardiovascular Diseases

作者：Hongjing Shi, Si Cheng, D J Y Sun, Yuting Han, Canqing Yu, D J Y Sun, P Pei, Ling Yang, Yuehua Chen, H D Du, Lingli Chen, Dan Schmidt, J S Chen, Z M Chen, Liming Li, J N Wei, Jun Lv, Robert Clarke, Rory Collins, Richard Peto, Robin Walters, Jun Lv, Yuanjie Pang, Can Hou, Qingmei Xia, Chao Liu, Lang Pan, Xiao Han, Honglu Bian, Xinxin Chen, Daniel Avery, Maxim Barnard, Derrick Bennett, Ruth Boxall, Jonathan Clarke, Ahmed Edris Mohamed, Hannah Fry, Prapthi Harish, Pek Kei Im, Andri Iona, Christiana Kartsonaki, Kshitij Kolhe, Hubert Lam, Kuang Lin, James Liu, Iona Millwood, Sam Morris, Qunhua Nie, Alfred Pozarickij, Maryam Rahmati, Paul Ryder, Maruf Sarder, Becky Stevens, Iain Turnbull, Baihan Wang, Lin Wang, Neil Wright, Xiaoming Yang, Pang Yao, Zengchang Pang, Ruqin Gao, Kunzheng Lv, Shanpeng Li, Haiping Duan, Shaojie Wang, Yongmei Liu, Ranran Du, Liang Cheng, Xiaocao Tian, Hua Zhang, Dan Hu, Xiaoyan Zheng, Yujie Wang, Wei Sun, Shichun Yan, Yong Zhou, Chi Wang, Zhenyuan Wu, Lishun Zhai, Zhaoxi Pang, Shiwen Dong, Li Liu, Dapeng Yin, Bin He, Ying Liu, Xingren Wang, Ou Ty, Xiangyang Zheng, Dewei Zheng, Shuai Yang, Lihui Li, Xingjiao Chen, Yan Xu, Jinyi Zhou, R C Tao, Jian Su, Xikang Fan, Xuejia Chen, Yuxiao Huang, Yan Lu, Y Q Hua, Li Xing, Shuxian Wang, Jianrong Jin, Juping Ma, Jinchao Liu, Kaifei Zhu, Hongfu Ren, Xingfeng Shen, G M Zhong, Wei Mao, Zhenzhen Lu, Yanxu Zhong, Lifang Zhou, Rong Pan, Jian Lan, Xiaoping Tan, Jinxue Tan, Yishan Xie, Liuping Wei, Liyuan Zhou, Sisi Wang, Xianping Wu, Ningmei Zhang, Xiaofang Chen, Xiaoyu Chang, Zhuo Wang, Yujin He, Mingqiang Yuan, Ling Wang, Zhaodong Wang, Qiang Sun, Yang Lin, Faqing Chen, Xiaolan Ren, Lijun Chang, Feiming Zhong, Jianjun Feng, Weijie Hu, Xiaofang Zhang, Yalin Chen, Honghong Wang, Jun Wang, Linqi Diao, Zhiwei Han, Dengjun Zhu, Kai Kang, Shixian Feng, Wenjie Yang, Huizi Tian, Yali Yan, Bing Han, 高丽, Li ShaoFang, Tianfang Xing, Wei Tang, Xiaolin Li, Huarong Sun, Xiaocong Zhao, Ying Li, Chen Hu, Pan He, Xukui Zhang, Yuanyuan Jin, Lan Luo, Min Yu, Ruying Hu, Hao Wang, Weiwei Gong, Jieming Zhong, Meng Wang, Chunxiao Xu, Keqing Gong, Hao Xu, Yuan Cao, Kaixu Xie, Tu Xd, Junlong Pan, Xiaojun Li, Li Yin, Huilin Liu, Yuan Liu, Lei Y, Xian Xie, Jing Wang, Bo Xiao, Zongwei Deng, Yuan Peng, Libo Zhang, Qu Cy, Li Deng, Qili Jiang, Yanling Chen, Jun Lv · 发表于：Journal of the American College of Cardiology · 年份：2026 · DOI：10.1016/j.jacc.2026.04.040 · 被引用次数：2 · 研究领域：Air Quality and Health Impacts、Air Quality Monitoring and Forecasting、Climate Change and Health Impacts

BackgroundEvidence linking components of particulate matter with diameters ≤2.5 μm (PM2.5) to the incidence of cardiovascular disease (CVD) remains scarce and inconsistent. ObjectivesThe aim of this study was to investigate the associations of long-term exposure to PM2.5 components with incident CVD risk, considering both absolute concentrations and relative proportions. MethodsThis study included 487,037 participants from the China Kadoorie Biobank who were free of CVD or cancer at baseline. Three-year moving average concentrations of PM2.5 and its components (black carbon [BC], organic matter, chloride [Cl−], nitrate [NO3−], sulfate [SO42−], and ammonium [NH4+]) were geocoded to participants at 1 × 1 km resolution according to their community recruitment clinic locations. Time-varying Cox proportional hazards models were used to evaluate the associations between PM2.5 components and incident CVD risk. Substitution models were used to estimate the effects of reallocating PM2.5 component proportions while keeping total PM2.5 mass constant, thereby evaluating changes in CVD risk associated with shifts in component composition. ResultsOver a median 15.1-year follow-up, a total of 196,224 CVD cases, including 72,747 of ischemic heart disease, 74,594 of ischemic stroke, 17,553 of hemorrhagic stroke, and 54,306 of other cerebrovascular diseases, were documented. Long-term exposure to PM2.5 components was associated with increased risk for CVD and its major subtypes. For total CVD,...