Supplemental Figure 12 from Increased Glucose Availability Sensitizes Pancreatic Cancer to Macrophage-Targeting Immunotherapies

作者：Jonathan J. Hue, Mehrdad Zarei, Priyashree Sunita, Sami O. Abul-Khoudoud, Goutam Dey, Hallie J. Graor, Katie E. Blise, Dove Keith, Shamilene Sivagnanam, Shakti Prasad Pattanayak, Erryk Katayama, Omid Hajihassani, Charles D. Lopez, Rosalie C. Sears, Robert Eil, Lisa M. Coussens, Jonathan R. Brody, Ali Vaziri‐Gohar, Jordan M. Winter · 年份：2026 · DOI：10.1158/2767-9764.32769823 · 研究领域：Cancer, Hypoxia, and Metabolism、Immune cells in cancer、Cancer Immunotherapy and Biomarkers

<p>Supplemental Figure 12 - Hyperglycemia is associated with an altered immune profile. Representative mIHC and immunofluorescence images of metastatic PDAC tumors obtained from non-hyperglycemic (left) and hyperglycemic (right) patients treated at OHSU. Single stained IHC images (top) depict tumor cells (PanCK), antigen-presenting cells (HLA-II), T cells (CD3), myeloid cells (CD 11b, CD163), and dendritic cells (CD11c). Immunofluorescence images (bottom) illustrate spatial relationships between cell populations in the tumor microenvironment. Scale bars, 250 µm.</p>