Pseudocapsule status combined with pathological parameters predicts prognosis in renal cell carcinoma

作者：Jiaxi Yao, Xi Wei, Hong Wang, Yiru Hou, feifei cui, Xi Chen, Huiling Sun, Ruirui Ma, Jianming Guo, Xiaoyi Hu · 发表于：Frontiers in Oncology · 年份：2026 · DOI：10.3389/fonc.2026.1779539 · 研究领域：Renal cell carcinoma treatment、Kidney Stones and Urolithiasis Treatments、Hemostasis and retained surgical items

Background We evaluated whether pseudocapsule status, alone and in combination with pathological parameters, could serve as a prognostic marker in human renal cell carcinoma (RCC). Methods We retrospectively analyzed 1560 patients with RCC who underwent surgery at a single institution between 2007 and 2012. The patients were randomly assigned to training (n=780) and validation (n=780) cohorts. Pseudocapsule status was classified as grade 0 (intact pseudocapsule without breakthrough), grade 1 (pseudocapsule invasion), and grade 2 (pseudocapsule breakthrough or absence). A pseudocapsule-pathological parameter score (PPS) was constructed by integrating pseudocapsule status with pathological type, Fuhrman grade, nuclear necrosis, sarcomatoid transformation, microvascular infiltration, Eastern Cooperative Oncology Group performance status score, and tumor-node-metastasis stage. The scores were categorized as low, intermediate, and high. Overall survival and relapse-free survival were evaluated using Kaplan–Meier and Cox regression analyses. Results Among the 1560 patients, 529 had grade 0 pseudocapsules, 701 had grade 1 pseudocapsules, and 330 had grade 2 pseudocapsules. The Kaplan–Meier curves revealed better overall survival in patients with grade 0 pseudocapsules than those with grades 1 and 2. Multivariate analyses identified grade 2 pseudocapsule status as an independent predictor of worse overall survival (hazard ratio 3.94, 95% confidence interval 2.09–7.43, p < 0.00...