DI treatment reduces T.gondii burden in the peritoneal fluid and tissues of infected mice.

作者：J Zhao, Linyan Bao (24239351), Huan Chen (6545), Tenglong Zhao, Dong Tang (104780), Yixi Sun (7371017), Yuqi Zuo (8697102), Jiafu Shang, Yanyan Liu (171941), Xuehui Zhou (24239357), Mengru Zhao, Xiaowei Yang (116246), Liwu Zhang (748578), Guangwei Zhao · 发表于：Figshare · 年份：2026 · DOI：10.1371/journal.pntd.0014454.g012 · 研究领域：Medicine、Surgery、Pathology、Internal medicine、Andrology、Immunology、Biology

T. gondii -infected mice (Tg group) were intraperitoneally inoculated with 100 tachyzoites. DI-treated groups received DI at doses of 40, 80, or 120 mg/kg, administered four hours post-infection. A Parasite load in mouse peritoneal fluid was determined by direct counting. Data are presented as mean ± SD (n = 15 mice per group). Statistical significance was determined by one-way ANOVA followed by Dunnett’s multiple comparisons test. * p < 0.05, *** p < 0.001. B-F: T. gondii DNA levels in cardiac, hepatic, pulmonary, splenic and renal tissues were quantified via qPCR. Data are presented as mean ± SD of 9 biological replicates (mice), with technical triplicates performed for each sample. Statistical significance was determined by one-way ANOVA followed by Dunnett’s multiple comparisons test. * p < 0.05, ** p < 0.01, *** p < 0.001, ns, not significant.