Association of Lipid and Inflammatory Profiles With Tumor Stage in Hepatocellular Carcinoma

作者：Nanmu Yang, Ting Wang, Xiangjun Qian, Z Y Li, Hao Wang, Hang Xing, Yuanlin Xu, Shuaiya Ma, Bo Meng, X. Zhang, Feng Han, Yongmei Li, Dongxiao Li, Hao Zhuang · 发表于：Cancer Medicine · 年份：2026 · DOI：10.1002/cam4.72049 · 研究领域：Cancer, Lipids, and Metabolism、Inflammatory Biomarkers in Disease Prognosis、Lipid metabolism and disorders

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Inflammatory responses and lipid metabolism disorders are known to influence cancer development; however, their combined effects on HCC progression remain unclear. This study examined the associations between lipid profiles and inflammatory markers with HCC stage. METHODS: In this cross-sectional study, data from 90 patients with HCC and available Barcelona Clinic Liver Cancer stage information were analyzed. Serum lipid profiles and inflammatory markers were measured, and derived indicators-including non-high-density lipoprotein cholesterol (non-HDL-C), the low-density lipoprotein cholesterol (LDL-C)-to-HDL-C ratio, the total cholesterol (TC)-to-HDL-C ratio, and the neutrophil-to-HDL-C ratio (NHR)-were calculated. Correlation analysis and logistic regression were performed with adjustment for potential confounders. Interaction analysis was conducted to examine relationships among lipid-inflammatory profiles, with findings validated in an independent cohort of 200 patients with HCC. RESULTS: HDL-C levels were significantly lower in patients with non-advanced stage tumors (0.81 ± 0.27 vs. 1.15 ± 0.28, p < 0.01). HDL-C showed a positive correlation with tumor stage (r = 0.544, p < 0.01), whereas non-HDL-C, LDL-to-HDL ratio, TC-to-HDL ratio, and NHR demonstrated negative correlations (r = -0.269, -0.568, -0.382, and -0.432, respectively; all p < 0.05). In univariate logistic regression analys...