A mineralizable and electroactive periosteum for promoting infected bone defect repair by remodeling the osteogenic microenvironment

作者：Yangyang Qu, Linghanqing Wang, Xinyue Yang, SHIXING LUO, Chongnan Yan, Nizhou Jiang, Yanchao Zhang, Jingyi Qu, S A Chen, Yuanming Xiao, Yifeng Shang, Li J, Ruiming Liang, Cheng Li, Li Li · 发表于：Chemical Engineering Journal · 年份：2026 · DOI：10.1016/j.cej.2026.178490 · 研究领域：Bone Tissue Engineering Materials、Planarian Biology and Electrostimulation、Calcium Carbonate Crystallization and Inhibition

The clinical management of infectious bone defects a formidable challenge. Existing periosteal substitutes do not actively modulate the dysregulated defective microenvironment or orchestrate a temporally ordered regenerative cascade. Therefore, an electroactive periosteum with an in situ–mineralized architecture, denoted as PCL/ZnO@PDA/HA (PZPH), is developed. This construct comprises a poly(ε-caprolactone) fibrous core incorporating piezoelectric ZnO, while a hydroxyapatite shell is formed on the surface via polydopamine-mediated biomimetic mineralization. The PZPH periosteum exhibits intelligent, stage-dependent regulatory functions during bone repair. In the early anti-infective phase, piezocatalysis generates reactive oxygen species and synergizes with sustained Zn 2+ release to confer robust antibacterial efficacy. During the subsequent regenerative phase, PZPH promotes M2 polarization in macrophages, enhances tube formation by endothelial cells, and facilitates osteogenic differentiation of bone marrow-derived mesenchymal stem cells. In a model of infected bone defect, PZPH-ultrasound stimulation effectively reconstructs a pro-regenerative microenvironment by enhancing angiogenesis and eliciting a regenerative immune response. Mechanistic investigations further reveal that these therapeutic effects are closely associated with Piezo1/Ca 2+ /CaMKII/PI3K–Akt signaling pathway activation. In conclusion, our findings propose a viable integrated therapeutic approach for infec...