Figure 2 from Elevated Tumor-Associated Androgen Receptor Activity Correlates with Poor Immune Infiltration and Immunotherapy Response across Cancer Types

作者：Ya‐Mei Hu, Faming Zhao, Julie N. Graff, Canping Chen, Yi Zhang, Jayne M. Stommel, Jinho Lee, Gabriel Mesquita Zangirolani, Joshua Rose, George Thomas, Hui Wu, Adel Kardosh, Gordon B. Mills, Joshi J. Alumkal, Amy E. Moran, Zheng Xia · 年份：2026 · DOI：10.1158/2767-9764.32729299 · 研究领域：Cancer Immunotherapy and Biomarkers、Ferroptosis and cancer prognosis、Prostate Cancer Treatment and Research

AR activity shows a strong negative correlation with genes involved in immune system processes. A, Evaluation of the correlation between AR activity and each gene expression within the entire dataset of each tumor type across all 33 TCGA cohorts. Heatmap displaying the 31 genes (rows) that are significantly correlated with AR activity across all 33 tumor types. Pearson correlation tests were used to calculate the correlation between AR activity and each gene’s expression in each cancer type. Significant correlations (P < 0.05) are indicated in red (positive correlation) or blue (negative correlation). Cancer types (columns) are sorted by decreasing mean correlation coefficient. B and C, Pathway enrichment analysis of the 31 AR activity–correlated genes. Dot plots indicating the top 15 significantly enriched GO BP terms (B) and Reactome pathways (C). The vertical axes represent the function classifications or pathways, and the horizontal axes represent the ratio of genes contained in the ontology or pathways. The dot’s color indicates the adjusted P value for enrichment significance, and the size of the dot indicates the number of genes in the functional class or pathway.