Supplementary Figure 3 from Bidirectional Association between Atrial Fibrillation and Ovarian Cancer: Evidence from the UK Biobank and Mendelian Randomization

作者：Z. Zhang, Na Zhang, Xinning Guo, Zhengyu Tao, Chen Wu, Qiming Liu, Ling Ding, Wutao Chen, Yu Zhong, Meng Jiang, Jun Pu · 年份：2026 · DOI：10.1158/1055-9965.32741043 · 研究领域：Atrial Fibrillation Management and Outcomes、Kruppel-like factors research、Folate and B Vitamins Research

<p>Supplementary Figure 3. Discovery of high-risk mutual genes expression of both AF and OCA. (A) Flowchart of discovering high-risk genes expression of both AF and OCA. (B) Summary of SNPs and mapped genes for AF and 4 OCAs using FUMA. (C) Tissue expression enrichment in GTEx general tissue types. The dashed line indicates the significance threshold at P < 0.001. (D) Bar-dot plots show significantly enriched gene sets annotation genes. (E) SMR analysis identifying genes with shared genetic associations between AF and OCA. Abbreviation: AF, atrial fibrillation; OCA, ovarian cancer; GWAS, genome-wide association studies; GTEx, Genotype-Tissue Expression; MR, mendelian randomization; NUP50, Nucleoporin 50; SMR, summary data-based mendelian randomization; SNP, single nucleotide polymorphisms; SYTL2, Synaptotagmin-like 2.</p>