Figure 1 from Novel Mechanism of and Therapeutic Approach for Anthracycline-Induced Cardiotoxicity

作者：Qingzhu Wang, Wanying Zhang, Josephine Chen, Kate Stenson, Shikha Parsai, Prerana Bangalore Parthasarathy, Chia‐Feng Liu, Thomas Garrett, Jung Lin, Anlin Hou, Riya A. Shimpi, Eric Gu, Mei Yin, Logan Shannon, Sadie Johnson, Belinda Willard, E. Rene Rodriguez, Charlie Androjna, Rohit Moudgil, Yilun Sun, Jennifer S. Yu, Christopher Nguyen, Tyler Alban, Timothy A. Chan, Sathyamangla V Naga Prasad, W.H. Wilson Tang, Jianhong Lin, Jianjun Zhao · 年份：2026 · DOI：10.1158/2767-9764.32730091 · 研究领域：Chemotherapy-induced cardiotoxicity and mitigation、Lung Cancer Research Studies、Cancer Treatment and Pharmacology

Doxorubicin induces TOP2B overexpression in human AIC specimens. A, Western blot analysis showing the expression levels of TOP2B and GAPDH in heart tissue samples from ND patients and patients with AIC. B, Hematoxylin and eosin stains of heart tissue sections from ND patients and patients with AIC, illustrating tissue morphology and cellular integrity. C, IHC staining showing the localization and expression of TOP2B in heart tissue sections from ND patients and patients with AIC. D, Masson’s Trichrome staining of heart tissue sections from ND patients and patients with AIC, highlighting fibrosis in purple color in the tissue.