Data from Anti-inflammatory Diet Index and Bladder Cancer Risk by Stage: A 22-Year Prospective Swedish Cohort Study (1998–2020)

作者：Samira Bernardino Ramos do Prado, Henrik Ugge, Anders Vikerfors, Katja Fall, Tahir Taj · 年份：2026 · DOI：10.1158/1055-9965.c.8547558 · 研究领域：Nutritional Studies and Diet、Inflammatory Biomarkers in Disease Prognosis、Bladder and Urothelial Cancer Treatments

<div>AbstractBackground:Dietary patterns influencing systemic levels of inflammation have been proposed and investigated as possible determinants of cancer risk. We evaluated the association between the anti-inflammatory potential of diet and the risk of bladder cancer.Methods:The anti-inflammatory diet index (AIDI), composed of 16 food groups (11 anti- and 5 pro-inflammatory), was used to score dietary patterns in N = 79,292 individuals derived from the Cohort of Swedish Men (established in 1997) and the Swedish Mammography Cohort (established in 1987). Dietary information was collected in 1997 and 2009; repeated-measures analyses used a cumulative-average AIDI. Incident bladder cancer cases were identified from the Swedish Cancer Register using International Classification of Diseases, 10th Revision code C67, and a baseline study questionnaire was used to assess covariates. We estimated multivariable hazard ratios (HR) across AIDI quartiles using Cox models.Results:After a 22-year follow-up, 1,165 individuals were diagnosed with bladder cancer, of whom 249 had non–muscle invasive bladder cancer (NMIBC), 201 had muscle-invasive bladder cancer (MIBC), and 715 had unknown stage. In repeated-measures analyses, the highest anti-inflammatory quartile (Q4) was associated with lower bladder cancer risk compared with the lowest quartile [Q1; HR, 0.74; 95% confidence interval (CI), 0.61–0.89]. Stratifying for tum...