Figure S17 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer

作者：Shenghe Deng, Jun Wang, Falong Zou, Denglong Cheng, Mian Chen, Junnan Gu, Jianguo Shi, Jia Yang, Yifan Xue, Zhenxin Jiang, Le Qin, Fuwei Mao, Xiaona Chang, Xiu Nie, Li Liu, Yinghao Cao, Kailin Cai · 年份：2026 · DOI：10.1158/0008-5472.32707580 · 研究领域：Cancer, Stress, Anesthesia, and Immune Response、Immune cells in cancer、NF-κB Signaling Pathways

<p>Figure S17: Animal models validated vanillylacetone inhibited PA-induced cytokine secretion and NF-to-CAF/mCAF activation. (A-B) Measurement of CSF-1, CXCL8, and TGF-β1 levels in CRC subcutaneous tumors and serum of C57BL/6 (A) and BALB/c (B) mice post-vanillylacetone treatment. (C) Immunofluorescence staining analysis of mCAFs in BALB/c mice subcutaneous tumors post-vanillylacetone treatment, green: FN1, red: α-SMA (Scale bars = 1mm and 20μm). (D) FN1-positive CAFs content in subcutaneous tumors from C57BL/6 and BALB/c mice post-vanillylacetone treatment. Statistical significance was determined by unpaired Student t test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, ns, no significance.</p>