Supplementary Figure 9 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity

作者：Xiaolin Wang, Hui Wang, Zhengjing Lu, Xiangjun Liu, Wenjia Chai, Wei Wang, Jun Feng, Yang Shen, Wei Yang, Haiyan Cheng, Chenghao Chen, Shihan Zhang, Nian Sun, Qiaoyin Liu, Qiliang Li, Wenqi Song, Fang Jin, Qi Zeng, Shengcai Wang, Yan Su, Huanmin Wang, Xin Ni, Jingang Gui · 年份：2026 · DOI：10.1158/0008-5472.32700344 · 研究领域：Neuroblastoma Research and Treatments、Cancer Immunotherapy and Biomarkers、Immune cells in cancer

<p>Supplementary Figure 9 The characteristics of NB tumors and immune cells in CD112/CD155 high-ratio and low-ratio groups revealed by bulk RNA sequencing analysis. (A) A total of 3537 DEGs between CD112/CD155 high-ratio and low-ratio groups (grouping according to the ratio median in the violin plot) are identified by RNA sequencing analysis with 38 NB tumor samples and illustrated in volcano plot. (B) The expression of genes related with neuroblastoma in KEGG pathway transcriptional misregulation in cancer is illustrated in heatmap. (C) and (D) The enriched top 20 KEGG pathways in high-ratio or low-ratio tumors are shown in dot plots. (E) and (F) The enriched top 30 GO pathways (top 10 in BP, CC and MF respectively) in high-ratio or low-ratio tumors are shown in dot plots. (G) and (H) The representative GSEA pathways enriched in high-ratio or low-ratio tumors are labeled with NES and p values.</p>