Supplementary Figure 5 from <i>KRAS</i> Loss of Heterozygosity Promotes MAPK-Dependent Pancreatic Ductal Adenocarcinoma Initiation and Induces Therapeutic Sensitivity to MEK Inhibition

作者：Sigrid K. Fey, Arafath K. Najumudeen, Dale M. Watt, Laura M. Millett, Catriona A. Ford, Kathryn Gilroy, Robert U. Simpson, Kathy McLay, Rosanna Upstill‐Goddard, David K. Chang, William Clark, Colin Nixon, Joanna L. Birch, Simon T. Barry, Jennifer P. Morton, Andrew D. Campbell, Owen J. Sansom · 年份：2026 · DOI：10.1158/0008-5472.32696867 · 研究领域：Melanoma and MAPK Pathways、Protein Tyrosine Phosphatases、NF-κB Signaling Pathways

<p>Loss of wild-type KRAS sensitizes KPC KrasG12D/fl tumours to MEK1/2 inhibition.</p>