Figure S3 from ETC-501 Is a Brain-Penetrant MNK Inhibitor That Potentiates TMZ-Induced Senescence and Sensitizes Glioblastoma Cells to Senolytic Therapy

作者：Giselle Sek Suan Nah, Yuk Kien Chong, Fatin Nasha Sulaimi, Kian Leong Lee, See Wee Lim, Qing You Pang, Mengge Yu, Zhen Wei Neo, Jabed Iqbal, Kassoum Nacro, Jeffrey Hill, Alex Matter, Henry Yang, Beng Ti Ang, Carol Tang, S. Tiong Ong · 年份：2026 · DOI：10.1158/0008-5472.32714892 · 研究领域：PI3K/AKT/mTOR signaling in cancer、Melanoma and MAPK Pathways、Telomeres, Telomerase, and Senescence

<p>ETC-501 reduces levels of p-eIF4E in a dose-dependent manner in GPCs and suppresses coagulation-related pathways in GBM cells</p>