Supplementary Figure 4 from KRAS Loss of Heterozygosity Promotes MAPK-Dependent Pancreatic Ductal Adenocarcinoma Initiation and Induces Therapeutic Sensitivity to MEK Inhibition

作者：Sigrid K. Fey, Arafath K. Najumudeen, Dale M. Watt, Laura M. Millett, Catriona A. Ford, Kathryn Gilroy, Robert U. Simpson, Kathy McLay, Rosanna Upstill‐Goddard, David K. Chang, William Clark, Colin Nixon, Joanna L. Birch, Simon T. Barry, Jennifer P. Morton, Andrew D. Campbell, Owen J. Sansom · 年份：2026 · DOI：10.1158/0008-5472.32696870 · 研究领域：Protein Tyrosine Phosphatases、PI3K/AKT/mTOR signaling in cancer、Protein Kinase Regulation and GTPase Signaling

<p>Loss of wild-type KRAS does not alter PI3K-AKT signalling.</p>