Figure S16 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer

作者：Shenghe Deng, Jun Wang, Falong Zou, Denglong Cheng, Mian Chen, Junnan Gu, Jianguo Shi, Jia Yang, Yifan Xue, Zhenxin Jiang, Le Qin, Fuwei Mao, Xiaona Chang, Xiu Nie, Li Liu, Yinghao Cao, Kailin Cai · 年份：2026 · DOI：10.1158/0008-5472.32707583 · 研究领域：Cancer, Lipids, and Metabolism、Cancer Research and Treatments、Cancer, Stress, Anesthesia, and Immune Response

<p>Figure S16: Vanillylacetone inhibited PA-induced CAF activation, ECM stiffness, and OCRC progression. (A) Tumor growth and mass measurements in C57BL/6 and BALB/c mice subcutaneous tumors following vanillylacetone treatment. (B-C) Analysis of lipid deposition, collagen fiber content, CAFs abundance, and ECM biomechanics properties in BALB/c tumors after vanillylacetone treatment (Scale bars = 1mm and 50μm; AFM 10μm). (D) Quantification of PA content in subcutaneous tumor from C57BL/6 and BALB/c mice after vanillylacetone treatment. Statistical significance was determined by unpaired Student t test and two-way ANOVA. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, ns, no significance.</p>