Supplementary Fig. S14 from Perivascular NOTCH3<sup>+</sup> Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy

作者：Abrar Choudhury, Martha A. Cady, Calixto‐Hope G. Lucas, Hinda Najem, Joanna J. Phillips, Brisa Palikuqi, Naomi Zakimi, Tara Joseph, Janeth O. Birrueta, William Chen, Nancy Ann Oberheim Bush, Shawn L. Hervey‐Jumper, Ophir D. Klein, Christine M. Toedebusch, Craig Horbinski, Stephen T. Magill, Aparna Bhaduri, Arie Perry, Peter J. Dickinson, Amy B. Heimberger, Alan Ashworth, Elizabeth E. Crouch, David R. Raleigh · 年份：2026 · DOI：10.1158/2159-8290.32702756 · 研究领域：Glioma Diagnosis and Treatment、Cerebrospinal fluid and hydrocephalus、Meningioma and schwannoma management

<p>Supplementary Fig. 14. Meningioma invasion of Virchow-Robin spaces. A, H&E low magnification (top) and high magnification (box, bottom) images of human meningioma invasion into perivascular fluid-filled cavities surrounding perforating vasculature of the brain. Densely cellular meningioma is shown at the top of each image, and islands of perivascular tumor within the brain parenchyma (dashed lines, bottom) are shown at the bottom of each image. Scale bars, 100µm. B, Low magnification (top) and high magnification (box, bottom) images of IHC for the brain parenchyma marker GFAP validates invasion of unlabeled meningioma cells into Virchow-Robin spaces without direct invasion of the brain parenchyma itself. C, IHC for the mural cell marker SMA (top) or the meningioma cell marker SSTR2A (bottom) validates meningioma invasion into Virchow-Robin spaces.</p>