Figure S2 from SOS1 Inhibition Enhances the Efficacy of KRAS<sup>G12C</sup> Inhibitors and Delays Resistance in Lung Adenocarcinoma

作者：Brianna R. Daley, Nancy E. Sealover, Bridget A. Finniff, Jacob M. Hughes, Erin Sheffels, Daniel Gerlach, Marco H. Hofmann, Kaja Kostyrko, Joseph P. LaMorte, Amanda J. Linke, Zaria Beckley, Andrew M. Frank, Robert E. Lewis, Matthew D. Wilkerson, Clifton L. Dalgard, Robert L. Kortum · 年份：2026 · DOI：10.1158/0008-5472.32697343 · 研究领域：Protein Kinase Regulation and GTPase Signaling、PI3K/AKT/mTOR signaling in cancer、Protein Tyrosine Phosphatases

<p>SOS1i synergizes with G12Ci to drive transcriptional changes regulating MAPK signaling.</p>