Supplementary Figure S1 from Discovery of a Long Half-Life AURKA Inhibitor to Treat MYC-Amplified Solid Tumors as a Monotherapy and in Combination with Everolimus

作者：Chun‐Ping Chang, Teng‐Kuang Yeh, Chiung‐Tong Chen, Wan-Ping Wang, Yen-Ting Chen, Chia‐Hua Tsai, Yan-Fu Chen, Yi‐Yu Ke, Jing-Ya Wang, Ching-Ping Chen, Tsung-Chih Hsieh, Mine-Hsine Wu, Chen‐Lung Huang, Ya-Ping Chen, Hong Zhuang, Ya‐Hui Chi · 年份：2026 · DOI：10.1158/1535-7163.32713026 · 研究领域：Synthesis and pharmacology of benzodiazepine derivatives、Biochemical and Molecular Research、Click Chemistry and Applications

<p>Supplementary Figure S1. Discovery and synthesis of 6K465. (A) Synthesis of pyrimidine derivatives Cmpd-T and 6K465 which possess a six-membered ring amine. (B) Western blot analysis for the expression of c-MYC and N-MYC respectively in NCI-H82 and SK-N-BE(2) cells treated with 1.0 or 5.0 uM of the indicated compounds for 2 hr.</p>