Figure S8 from A Novel Designed Anti–PD-L1/OX40 Bispecific Antibody Augments Both Peripheral and Tumor-Associated Immune Responses for Boosting Antitumor Immunity

作者：Baocun Li, Shiyong Gong, Nianying Zhang, Beilei Shi, Zhou Lv, Yu Zhang, Naren Gaowa, Liqin Dong, Danqing Wu, Jianfu Wu, Fan Liu, Rui Zhang, Ramin Behzadigohar, Vinod Ganju, Chengbin Wu, Xuan Wu · 年份：2026 · DOI：10.1158/1535-7163.32715389 · 研究领域：Monoclonal and Polyclonal Antibodies Research、Cancer Immunotherapy and Biomarkers、Immunotherapy and Immune Responses

<p>Supplementary. Fig. 8. EMB-09 induces TEM expansion in peripheral immune system from hPD-L1/hOX40 transgenic C57BL/6 mice bearing MC38-hPD-L1 tumor. a Schematic representation of experimental design for blood, spleen, tumor sample collection and staining. b flow cytometry analysis of CD4 and CD8 TEM in spleen. c Flow cytometry analysis of CD4+ and CD8+ TEM in blood. d Flow cytometry analysis of CD4 and CD8 central memory T cells (CD44+CD62L+) in blood. e Flow cytometry analysis of TILs. Data are shown as mean ± SD, followed analysis by one-way ANOVA and Tukey’s multiple comparisons test. ns., not significant. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.</p>