Supplementary Figure S4 from Discovery of a Long Half-Life AURKA Inhibitor to Treat MYC-Amplified Solid Tumors as a Monotherapy and in Combination with Everolimus

作者：Chun‐Ping Chang, Teng‐Kuang Yeh, Chiung‐Tong Chen, Wan-Ping Wang, Yen-Ting Chen, Chia‐Hua Tsai, Yan-Fu Chen, Yi‐Yu Ke, Jing-Ya Wang, Ching-Ping Chen, Tsung-Chih Hsieh, Mine-Hsine Wu, Chen‐Lung Huang, Ya-Ping Chen, Hong Zhuang, Ya‐Hui Chi · 年份：2026 · DOI：10.1158/1535-7163.32713017 · 研究领域：Cell death mechanisms and regulation、Peptidase Inhibition and Analysis、Glioma Diagnosis and Treatment

<p>Supplementary Figure S4. DBPR728 induces consecutive cell apoptosis. (A) Quantification of the pH3Ser10 and NEUROD1 levels in the xenografts measured by Western analysis (Fig. 4B). Errors are mean ± SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001 (t-test, two-tailed). (B) Immunohistochemical analysis for the expression of cleaved Caspase-3 to mark apoptotic cells in NCI-H446 tumor xenografts harvested from mice described in Fig. 4A.</p>