Figure S12 from Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer

作者：Shenghe Deng, Jun Wang, Falong Zou, Denglong Cheng, Mian Chen, Junnan Gu, Jianguo Shi, Jia Yang, Yifan Xue, Zhenxin Jiang, Le Qin, Fuwei Mao, Xiaona Chang, Xiu Nie, Li Liu, Yinghao Cao, Kailin Cai · 年份：2026 · DOI：10.1158/0008-5472.32707595 · 研究领域：Cancer, Stress, Anesthesia, and Immune Response、Metabolism, Diabetes, and Cancer、Pharmacological Effects of Medicinal Plants

<p>Figure S12: PA stimulates NF-to-mCAF activation by stimulating CRC cells to secrete CSF-1, TGF-β1, and CXCL8. (A) Volcano plot of differentially expressed genes in SW480 cells after PA stimulation. (B-C) KEGG (B) and GO (C) enrichment analysis of differentially expressed genes. (D) Cellular multiplex immunofluorescence staining confirmed that PA promotes NFs to mCAFs activation by stimulating CRC cells to secrete CSF-1, TGF-β1, and CXCL8 (Scale bars = 20μm).</p>