Supplementary Fig. S1 from Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy

作者：Abrar Choudhury, Martha A. Cady, Calixto‐Hope G. Lucas, Hinda Najem, Joanna J. Phillips, Brisa Palikuqi, Naomi Zakimi, Tara Joseph, Janeth O. Birrueta, William Chen, Nancy Ann Oberheim Bush, Shawn L. Hervey‐Jumper, Ophir D. Klein, Christine M. Toedebusch, Craig Horbinski, Stephen T. Magill, Aparna Bhaduri, Arie Perry, Peter J. Dickinson, Amy B. Heimberger, Alan Ashworth, Elizabeth E. Crouch, David R. Raleigh · 年份：2026 · DOI：10.1158/2159-8290.32702771 · 研究领域：Meningioma and schwannoma management、Brain Metastases and Treatment、Glioma Diagnosis and Treatment

<p>Supplementary Fig. 1. Single-cell RNA sequencing of human meningiomas with loss of chromosome 22q. A, Single-cell counts across UMAP clusters from human meningioma samples with loss of chromosome 22q analyzed using single-cell RNA sequencing. B, UMAP showing single-cell RNA sequencing of human meningioma samples shaded by sample of origin. C, Stacked bar plots showing the distribution of chromosome 22q loss (red) across single-cell RNA sequencing clusters from human meningioma samples. D, UMAP and stacked bar plot showing single-cell RNA sequencing cell cycle analysis across human meningioma samples. E-G, Heatmap and feature plots showing differentially expressed genes across UMAP clusters from human meningioma samples analyzed using single-cell RNA sequencing. Colors as in A. See also Supplementary Table 1. G, Feature plots showing expression of meningioma (SSTR2, PTGDS) or cancer stem-cell markers (NOTCH3, THY1) across UMAP clusters from human meningioma samples analyzed using single-cell RNA sequencing.</p>