Supplementary Fig. S9 from Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy

作者：Abrar Choudhury, Martha A. Cady, Calixto‐Hope G. Lucas, Hinda Najem, Joanna J. Phillips, Brisa Palikuqi, Naomi Zakimi, Tara Joseph, Janeth O. Birrueta, William Chen, Nancy Ann Oberheim Bush, Shawn L. Hervey‐Jumper, Ophir D. Klein, Christine M. Toedebusch, Craig Horbinski, Stephen T. Magill, Aparna Bhaduri, Arie Perry, Peter J. Dickinson, Amy B. Heimberger, Alan Ashworth, Elizabeth E. Crouch, David R. Raleigh · 年份：2026 · DOI：10.1158/2159-8290.32702714 · 研究领域：Meningioma and schwannoma management、Brain Metastases and Treatment、Glioma Diagnosis and Treatment

<p>Supplementary Fig. 9. WHO grade 3 meningioma immunofluorescence microscopy for NOTCH3 and the endothelial cell marker VWF. NOTCH3 is expressed in and out of the perivascular niche, and is adjacent to endothelial cells in the perivascular niche, in meningiomas with WHO grade 3 histology. SF numbers indicate individual meningiomas. Representative of n=10 WHO grade 3 meningiomas. WHO grade defined using histological criteria. Scale bars, 10µm.</p>