Figure 5 from Interleukin-34–Induced Arg1<sup>+</sup> Macrophages Play a Key Role in Breast Cancer Brain Metastasis

作者：Xiaoqing Cheng, Khooshbu Kantibhai Patel, Brandon Zhou, Yiwei Fu, Ryan T. Cleary, Maureen Highkin, Jacob Hsia, Xiaohua Jin, Benjamin Kohn, Julie L. Prior, Megan S. Michie, Rui Sun, Xu Cheng, Liwei Bao, Jason Heth, Tusharika Rastogi, Amanda E.D. Van Swearingen, James D. Quirk, Ian S. Hagemann, Aki Morikawa, Nathan Merrill, Sofía D. Merajver, Qingyun Li, Katherine E. Schwetye, Vaibhav Jain, Simon G. Gregory, Albert H. Kim, Ron Bose · 年份：2026 · DOI：10.1158/2767-9764.32658232 · 研究领域：Neuroinflammation and Neurodegeneration Mechanisms、Immune cells in cancer、Single-cell and spatial transcriptomics

<p>Enrichment of pathways and cell types in the spatial landscape of tumor, invading, and normal cerebellum clusters. <b>A,</b> Gene sets significantly enriched in tumors compared with normal cerebellum as identified via GSEA (<i>P</i> < 0.05). ES (enrichment score) and −log<sub>10</sub> (<i>P</i> values) of pathways are shown. GSEA was performed using the hallmark gene sets in the Molecular Signatures Database (version 7.5.1). A list of the hallmark genes in replicate one is provided in Supplementary Table S3. <b>B,</b> Gene sets significantly enriched in tumors compared with invasion clusters as identified via GSEA (<i>P</i> < 0.05). ES (enrichment score) and −log<sub>10</sub> (<i>P</i> values) of pathways are shown from GSEA performed using hallmark gene sets in the Molecular Signatures Database (version 7.5.1). A list of the hallmark genes in replicate one is provided in Supplementary Table S3. <b>C,</b> Integrated spatial distribution panel of cell types of prediction in duplicate samples. Cell types are identified by a combination of snRNA and spatial transcriptomics technology. <b>D,</b> Spatial distribution of macrophages as indicated in duplicate samples. <b>E,</b> Spatial distribution of Arg1 as indicated in duplicate samples.</p>