Targeting ATF3-mediated asparagine biosynthesis reverses acquired resistance to KRASG12C inhibitors

作者：Yanjing Zhu, Chi Zhang, Min Li, Luoyan Ai, Fan Xu, Yiyi Yu, Shan Yu, Xiaojing Xu, Qing Liu, Mengxuan Zhu, M Y Liu, Jingyuan Wang, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Rui Wu, Ke Peng, Tianshu Liu · 发表于：Oncogene · 年份：2026 · DOI：10.1038/s41388-026-03838-1 · 研究领域：Endoplasmic Reticulum Stress and Disease、Cancer, Hypoxia, and Metabolism、Amino Acid Enzymes and Metabolism