Longitudinally recurring clonotypes.

作者：A.W. Myers, Monika Chandravanshi, Leanne S. Whitmore, Brendan F. Kohrn, Amina Negash, Dung N. Nguyen (6308711), Pooja Ralli-Jain, Kendra Cruickshank (24141799), Amit A. Upadhyay, Tysheena Charles, Christopher T. Edwards, Eric Hunter (117369), Rama R. Amara, Marek K. Korzeniowski, Ling Niu (4423711), Edwin Pozharski, William D. Tolbert, Steven E. Bosinger (8777792), Scott R. Kennedy, Marzena Pazgier, Cynthia A. Derdeyn · 发表于：Figshare · 年份：2026 · DOI：10.1371/journal.ppat.1014268.s002 · 研究领域：Biology、Medicine、Immunology、Computer science

(A) 109 clonotypes were detected in at least 3 of 5 immunization phases: Post-SOSIP 1 (weeks 18, 20); Post-SOSIP 2 (weeks 26, 36), Post-SOSIP 3 (weeks 48, 49), Post-SOSIP 4 (weeks 80, 81, 83), Challenge (weeks 87, 93). These clonotypes were used to evaluate divergence from V H germline over time as shown in Fig 1C. The six clonotypes of interest are indicated by arrows (684, 695, 1303, 385, 386, 599) and more detailed information is shown in (B) , including V H and V L gene germline call, CDRH3 length, clonotype size, and the time points in which the clonotype was detected. (TIF)