Migraine and Stroke Risk in Postmenopausal Women in the Women's Health Initiative

作者：Tracy E. Madsen, Christina Raker, Jelena M. Pavlovic, Laura B. Harrington, Peter F. Schnatz, Marcia L. Stefanick, Matthew Allison, Aladdin H. Shadyab, Simin Liu, Donald Penzien, Bernhard Haring, Robert Wild, Longjian Liu, Nazmus Saquib, J Wactawki-Wende, Farha Ikramuddin, Michael J. LaMonte, J E Manson, Brian Silver · 发表于：Neurology · 年份：2026 · DOI：10.1212/wnl.0000000000214825 · 被引用次数：1 · 研究领域：Migraine and Headache Studies、Neurological Complications and Syndromes、Menopause: Health Impacts and Treatments

BACKGROUND AND OBJECTIVES: Migraine is a known risk factor for stroke in women of reproductive age, although its relationship with stroke among postmenopausal women remains unclear. We assessed the association between migraine history and incident stroke in a sample of postmenopausal women. METHODS: We included women enrolled in the Women's Health Initiative, a large US longitudinal cohort study of postmenopausal women, and excluded those with previous stroke or those with missing data on key variables. The primary exposure was self-reported, physician-diagnosed migraine at baseline, and the primary outcome was incident stroke (total, ischemic, or hemorrhagic). Multivariable Cox proportional hazards models were used to test the cause-specific hazard ratios (HRs) between migraine history and total, ischemic (overall and by subtype), and hemorrhagic stroke, sequentially adjusted for age, traditional cardiovascular risk factors, and female-specific risk factors (age at menopause, age at menarche, menstrual irregularity, presence of vasomotor symptoms, parity, breastfeeding, and use of menopausal hormone therapy). We then quantified the association between a history of migraine and total stroke by age at baseline (in 5-year age groups) using multivariable models. Data on the presence of aura and migraine frequency were not available. RESULTS: Participants (N = 130,277) had a median age of 63 years (interquartile range [IQR] 57-69). A total of 5,743 incident stroke events occurred...