WHO estimates of the global, regional, and national burden of 42 foodborne infectious and chemical hazards, 2000–21: an updated data synthesis

作者：Robin Lake, Brecht Devleesschauwer, Shannon E Majowicz, Lucy Jane Robertson, Lea Sletting Jakobsen, Antonio Agudo, Sara M. Pires, Martyn D. Kirk, Elaine Scallan Walter, Karen Helena Keddy, Carlotta Di Bari, Louise Vaes, Arie Hendrik Havelaar, Charlee Roberts, Tesfaye Gobena, Mirjam E Kretzschmar, Gabriela F. Nane, Sandra Hoffmann, Lapo Mughini-Gras, Banchob Sripa, Kunihiro Kubota, Luria Leslie Founou, Li Bai, Mohammed Al Huthiel, Tety Rachmawati, Teresa Estrada‐García, Ashok Kumar, Fadi Al Natour, Steven Jaffee, Spencer Henson, Luc Ingenbleek, Richard Kumapley, Elaine Borghi, Yuki Minato · 发表于：The Lancet Global Health · 年份：2026 · DOI：10.1016/j.langlo.2026.103994 · 被引用次数：18 · 研究领域：Food Safety and Hygiene、Salmonella and Campylobacter epidemiology、Zoonotic diseases and public health

BACKGROUND: Foodborne diseases are important causes of illness and death. The first estimates of their burden were published by WHO in 2015. We updated WHO estimates of the global, regional, subregional, and national foodborne disease burden caused by 42 infectious and chemical hazards in 2021, including time trends for 2000-21. METHODS: We provide a high-level summary of foodborne disease burden, expressed as incidence, deaths, and disability-adjusted life-years (DALYs). Data for burden estimation were provided from a WHO-commissioned series of systematic reviews on the incidence, aetiology, sequelae, and case fatality or mortality of the hazards. Data were analysed using hierarchical meta-regression modelling with geographical clustering and a global linear time trend, disease-specific computational models, and uncertainty propagation through Monte Carlo simulations to calculate 95% uncertainty intervals. Attribution to foodborne transmission was principally based on a structured expert judgement process. Economic impact was measured as lost productivity. FINDINGS: For 2021, foodborne transmission of the 42 hazards caused 866 million (95% uncertainty interval 680-1090) illnesses, 1·52 million (0·783-2·51) deaths, and 57·1 million (39·4-81·1) DALYs. Inorganic arsenic, lead, and non-typhoidal Salmonella enterica (diarrhoeal and invasive disease) resulted in the most DALYs. The greatest burden of foodborne disease was in the African and South-East Asia regions. The incidence i...