Figure S7 from DDR1 Promotes Immune Evasion in Colorectal Cancer by Orchestrating IL33-Mediated M2-like Polarization of Tumor-Associated Macrophages

作者：Xiaofan Duan, Gaoshaer Yeerkenbieke, Yanjun Feng, Mingwang Zhou, Yumei Zhang, Jiuli Zhou, Jin Li · 年份：2026 · DOI：10.1158/2326-6066.32541444 · 研究领域：Immune cells in cancer、IL-33, ST2, and ILC Pathways、Cancer Immunotherapy and Biomarkers

<p>Figure S7. DDR1 promotes immune evasion in CRC via the DDX21-c-Jun-IL-33 axis driving M2-like TAM polarization, related to Fig.7. A) Immunofluorescence images of CRC tumor tissues (<i>n</i> = 99) demonstrate the co-localization of DDR1 with DDX21, phospho-c-Jun (p-c-Jun), and M2-like TAM infiltration. Scale bar: 20 µm. B) Correlation between DDR1 mRNA expression and levels of M2-like macrophage marker genes (CD206, ARG1) in public CRC transcriptomic cohorts. Data are presented as mean ± SEM. P values were calculated by the Pearson correlation test (B).</p>