A role for nucleolin in functional improvement in stroke

作者：Samuel P. Bridges, Mary Hovanesyan, Srbui Azarapetian, Ofri Abraham, Ida Rishal, Mike Fainzilber, S. Thomas Carmichael · 发表于：iScience · 年份：2026 · DOI：10.1016/j.isci.2026.116134 · 研究领域：Neuroinflammation and Neurodegeneration Mechanisms、Neurogenesis and neuroplasticity mechanisms、Muscle Physiology and Disorders

Stroke remains a global health concern and a leading cause of adult-onset disability due to limited intrinsic repair capability. Here, we identify nucleolin as a targetable regulator of the repair programs activated following ischemic injury. Through neuron-specific subcellular targeting of axonal nucleolin in the post-stroke recovery period, we see enhanced axonal sprouting and accelerated functional recovery following motor cortex stroke. These findings demonstrate that interference in localized nucleolin functions following cortical stroke is a viable strategy to enhance functional recovery.