Discovery of Rearranged Steroids from Cultures of Penicillium soli as Inhibitors of Idiopathic Pulmonary Fibrosis

作者：Ming Chen, Xueqi Lan, Xue Gong, Xinye Huang, Dechao Meng, W J Sun, Chao Zhao, Changxing Qi, Y C Zhang · 发表于：Journal of Natural Products · 年份：2026 · DOI：10.1021/acs.jnatprod.6c00334 · 研究领域：Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis、Lung Cancer Treatments and Mutations、Antifungal resistance and susceptibility

exhibited antifibrotic activity by suppressing TGF-β1-driven fibroblast activation and extracellular matrix production in NIH/3T3 cells. The same compound alleviated the pathological changes in the bleomycin-induced IPF mice, that might provide a potential lead compound in the drug development for IPF.