Mutation Profiling, Efficacy Monitoring, and Prognosis Evaluation Using Circulating Tumor DNA in Peripheral T ‐Cell Lymphoma: A Prospective, Multicenter, Observational Study

作者：Donglu Zhao, Y Song, Qin JiaYue, Tong Hongyan, Ding Kaiyang, Cai Qingqing, Huiqiang Huang, Wu Lili, Jing Hongmei, Liling Zhang, Qian Wenbin, Bai Ou, Cao Shanbo, Jin Jie, Zhu Jun, Ma Jun · 发表于：American Journal of Hematology · 年份：2026 · DOI：10.1002/ajh.70357 · 被引用次数：1 · 研究领域：Lymphoma Diagnosis and Treatment、Cancer Genomics and Diagnostics、T-cell and Retrovirus Studies

Peripheral T-cell lymphoma (PTCL) represents a diverse and aggressive category of hematologic malignancies that significantly affects patient outcome [1]. PTCL is characterized by multiple subtypes, including NK/T-cell lymphoma (NKTCL), angioimmunoblastic T-cell lymphoma (AITL), anaplastic large cell lymphoma (ALCL), and PTCL, not otherwise specified (PTCL-NOS), and is associated with considerable morbidity and mortality, primarily due to poor response to conventional therapies [2-4]. Recent advancements in molecular diagnostics have highlighted circulating tumor DNA (ctDNA) as a valuable biomarker for various cancers, providing real-time insights into tumor dynamics and treatment responses [5-7]. Previous studies have established the role of ctDNA in assessing tumor burden, prognostication, and monitoring treatment efficacy across several hematological malignancies [8-10]. Moreover, identifying specific ctDNA alterations associated with treatment response may enhance prognostic evaluation and support therapeutic decision-making [11, 12]. Despite its promising potential, significant gaps remain regarding the clinical applicability of ctDNA in PTCL. In particular, comprehensive and prospective studies examining the association between ctDNA dynamics and treatment outcomes across different PTCL subtypes are lacking. To address these gaps, we conducted a prospective, multicenter, observational cohort design using next-generation sequencing (NGS) to analyze tumor DNA (tDNA) and p...