Prognostic Significance of Pretreatment Blood‐Based Biomarkers in Penile Cancer: A Multicenter Retrospective Study in Japan

作者：Shuichi Tatarano, Makito Miyake, Yu Osaki, Kei Daizumoto, Koichiro Wada, Keita Kobayashi, Minoru Kato, Hideo Fukuhara, Takuya Tsujino, Kohei Kobatake, Rikiya Taoka, Junya Furukawa, Kohei Ogawa, Koji Shiraishi, Taisuke Matsue, Keiji Inoue, Ryoichi Maenosono, Yohei Sekino, Kiyohide Fujimoto, Hideki Enokida · 发表于：International Journal of Urology · 年份：2026 · DOI：10.1111/iju.70507 · 被引用次数：3 · 研究领域：Genital Health and Disease、Inflammatory Biomarkers in Disease Prognosis、Cancer Diagnosis and Treatment

OBJECTIVES: Penile cancer is a rare malignancy, and multicenter data evaluating prognostic biomarkers in the Japanese population are limited. This study aimed to assess the prognostic significance of pretreatment blood-based biomarkers in patients with penile cancer. METHODS: We conducted a multicenter retrospective cohort study including 111 patients with penile cancer treated between January 2005 and December 2023 at ten institutions participating in the West Japan Uro-oncology Collaboration Group. Cancer-specific survival (CSS) was analyzed using the Kaplan-Meier method and Cox proportional hazards model. Receiver operating characteristic analyses were performed to determine optimal cutoff values for the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and squamous cell carcinoma antigen (SCC-Ag). A composite biomarker score was calculated based on the number of elevated biomarkers. RESULTS: The 5-year overall survival and CSS rates were 71.1% and 77.4%, respectively. In univariate analyses, elevated PLR, elevated SCC-Ag, and higher composite biomarker scores were significantly associated with poorer CSS. In multivariate analysis, advanced clinical nodal status (≥ cN2) and distant metastasis (cM1) remained independent predictors of CSS, whereas blood-based biomarkers did not retain independent prognostic significance after adjustment for established clinicopathological factors. Kaplan-Meier analyses demonstrated significantly worse CSS in patients ...