Methodology and baseline characteristics of the China Migraine registry (CHIME): a nationwide, multi-center, prospective cohort study of 11,814 patients

作者：Ye Ran, Zizi He, Xun Han, Hui Su, Mingjie Zhang, Shuhua Zhang, Longteng Ma, Shengyuan Yu, Zhao Dong, on behalf of the Korean Familial Hypercholesterolemia (KFH) Registry Investigators, C F Chen, Hong Ye, Min Cheng, Liang Zhang, Ligong Zhang, Suiyi Xu, Li Li, J Zhou, Guogang Luo, Yajun Lian, Dongjun Wan, Yuanrong Yao, Hui Xue, 余能伟, Kunlin Zhang, Li Mei, Hui Li, Qi Li, Ping Gu, Zhenguo Liu, Kaiming Liu, Wenping Gu, Hongli Qu, Zheman Xiao, Xianliang Li, 黄仕雄, Jie Zhang, Ming Dong, Hang Shen, Hebo Wang, Peng Feng, Zhongling Zhang, Zi Wang, Le Chen, Hongbin Cai, Taiqing Zhu, Yangmei Chen, Jiasi Li, Yi-Xiang Wang, Xijin Wang, Jie Yang, Chengjie Mao, Y Wu, Qiuling Tong, Wei Gui, Wei Shao, Yuhu Zhang, Xiaojuan Wang, Sufen Chen, Wei Wu, Huixing Wei, Hongxing Liu, Hanxing Liu, Yungang Cao, Li’an Huang, Xuying He, Haiyan Li, Zhaoli Ge, Gesheng Lei, Xianguo Jiang, Chengqing Zhong, Shilun Zuo, Peiwei Hong, Li Zhou, Peng Xu, Xueqian Yuan, Qian Tian, Shuqin Zhan, Li Ren, Na Zhao, 苑振云, Zhengyu Sun, 程南方, Yuzhou Guo, Haiyan Yu, Yafei Wang, Bingmei Deng, Lei Zhang, Ying Zhou, Lu Liu, Dan Wang, Feng Wang, Chaohui Tang, Ran Zhang, Y Zhang, Hao Chen, C F Chen, Juan Ma, Xin Wang, Rong Fu, Le Chen, Y Zhang, Lin Li, 蒋欣作, Tianxia Zhang, Xiaoyu Gao, Dongmei Hu, Min Ye, Yunliang Xie, Shuhua Gui, Lian Zuo, 卢振产, Faming Wang, Jinfeng He, Jianjun Chen, Li Yunfei, Liu Z, Shuisheng Zhong, Wei Sun, Gang Li, Yi-Xiang Wang, Huipian Lai · 发表于：The Journal of Headache and Pain · 年份：2026 · DOI：10.1186/s10194-026-02389-w · 研究领域：Migraine and Headache Studies、Neurological Complications and Syndromes、Cerebrovascular and genetic disorders

BACKGROUND: Migraine is the leading cause of years lived with disability (YLDs) in young and middle-aged populations globally. Despite strategic initiatives to standardize headache care in China, large-scale real-world evidence regarding clinical management patterns remains sparse. The China Migraine Registry (CHIME) was established to bridge this gap. This study aims to delineate the CHIME methodology and report the baseline clinical characteristics, diagnostic accuracy, and therapeutic patterns of its initial cohort. METHODS: CHIME is a nationwide, multi-center, prospective, longitudinal cohort study involving over 100 specialized headache centers across 28 provinces in China. Initiated in May 2024, the study utilizes a proprietary digital health platform integrated with a clinical decision support system (CDSS 2.0) for headache disorders. Data collection encompasses structured clinical profiles, patient-reported outcomes, and specialized sub-study cores. This baseline analysis details the cross-sectional characteristics of patients enrolled through February 15, 2026. RESULTS: Among 11,814 participants (79.43% female; mean age 37.42 ± 10.94 years), 10,123 (85.7%) had episodic migraine (EM), 1,019 (8.6%) had chronic migraine (CM), and 672 (5.7%) had probable migraine. A profound diagnostic-therapeutic gap was identified: only 31.0% of patients had received a correct prior diagnosis. Paradoxically, 91.43% had undergone auxiliary investigations, primarily cranial imaging (87.3...