Safety and efficacy of astegolimab for COPD with frequent exacerbations regardless of baseline blood eosinophil counts (ALIENTO and ARNASA): randomised, double-blind, placebo-controlled, phase 2b and 3 trials

作者：Alberto Papi, Neil Greening, Surya P Bhatt, N Roche, Bartolome Celli, Jadwiga A Wedzicha, A Agusti, Ruth Tal-Singer, MeiLan K Han, Wim Janssens, Nicola A Hanania, Parameswaran Nair, Peter Bremner, Κonstantinos Porpodis, Yoko Shibata, Stephanie Korn, T Yang, Oliver Gordon, Rebecca Saenz, Julie Ng, Dorothy Cheung, Jacob Devine, Michele A. Grimbaldeston, Wenhui Zhang, Xiaoying Yang, Divya Mohan, Claus F Vogelmeier, Christopher E Brightling, Joanna Abbott, A. Abriel, Ismail Abdullah, Idalia Acosta, Yochai Adir, Puneet Agarwal, Syed Ahmed, Joong Hyun Ahn, Aalia Al-Barwani, Bernardino Alcazar, Soledad Alonso Viteri, Hector Altieri, Carlos Antonio Amado Diago, Laurentia Doina Andrei, Syed Anees, Joong Hyun Ahn, Katerina Antoniou, Ghiulten Apti, Justin Arambasick, Alvaro Aranda, German Arce, Ahmed Arif, Chandra Armstrong, Piyush Arora, Todor Atanasov, FRANCIS AVERILL, Dina Fathy Awad, Nina Azarov, Aurika Babjoniševa, Mona Bafadhel, Akash Balki, Sabine Ballenberger, Anup Banerjee, Sandeep Bansal, Amir Bar-Shai, Sandra Been-Buck, Adrian Beltran-Martinez, Eli John Berame, Neville Berkman, Andrea Bianco, Tao Bian, Daniela Blanco, Uffe Bødtger, Andreas Bonitz, Watchara Boonsawat, Peter Bosson, Zuzana Kalcikova Bouckova, Nagaraju Boyilla, Shari Brazinsky, Benjamin Bregman, Benedict Brockway, Judith Brown, Horacio Budani, Stephan Budweiser, Hina Budhwani, Māris Bukovskis, Luis Mateos Caballero, Jorge Calle Medina, Víctor Cambursano, Jie Cao, María del Puerto Cano Aguirre, C. Carlsten, Claudia Cartagena Salinas, Jose Cevallos-Yepez, Marco Chahuan Yumha, James Chalmers, Catherina Chang, Kenneth Chapman, William Chávez Frías, Bi Chen, Liang Chen, Shih-Lung Cheng, Chih‐Feng Chian, Pai-Chien Chou, Gourab Choudhury, Robert Chrzanowski, Ivana Čierná-Peterová, Jeremy Cole, Liana Correa, A G Corsico, Michael Crooks, Humberto Cruz, Dan Curiac, Karen Czischke Ljubetic, Fabian Dabove, Huw Davies, Bethany Davis, Kevin DeBoer, Regina Deckelmann, Teresita De Guia, Gustavo de Luiz Martinez, Douwe de Jong, Marc De Meulemeester, Michael Denenberg, Zhiping Deng, María De Salvo, Gastón De Stefano, Raja Devanathan, Gilles Devouassoux, Peter de Vries, Anil Dhar, Jose Diaz, Jacqueline Diaz, Mariya Dimitrova, Dimo Dimov, Krasimir Donchev, Limin Dong, Yaniv Dotan, Youcef Douadi, Jacek Dulęba, Jack Dummer, Natalie Duric, Luc Dussart, Andres Echazarreta, Andrew Edwards, Martin Ehlers, Pedro Elias, Rani Elenjical, Michael Epton, David Erb, Andrea Esponda, Neil Ettinger, Faisal Fakih, Haohui Fang, Humam Farah, Karen Faulkner, Edward Federman, Jan Feimer, Rosa Feijoó Seoane, G Feldman, Jiaxi Feng, Jia-Yih Feng, Marcelo Fernandez, Rocio Fernandez Bazerque, Gershon Fink, Elie Fiss, Florian Fliedner, Linda Ford, Andreas Forster, Karin Förster, Nyda Fourie, Benjamin Fox, Maria Franchi, Marta Frejowska-Reniecka, Sara Fristorp Cesarini, David Fuentes, Muhammed Fulat, Jonathan Fuld, Sławomir Garbicz, Gabriel Garcia, Mireya Garcia, Francisco De Borja García-Cosío Piqueras, Francisco Garcia-Rio, Robert Garver, Grzegorz Gąsior, Gabriel Gattolin, Timothy Gatheral, Priscila Geller Wolff, Elpiniki Georgatou-Papageorgiou, Mariela Georgieva, Rosen Georgiev, Hanna Gęsińska, Dipansu Ghosh, John Giessing, Jesse Gitaka, Bradford Glavan, Matthew Glaves, Wolfgang Gleiber, Edgar Gonzalez, Carolina Maria Gotera Rivera, Izabela Grabska-Kobyłecka, Sandeep Kumar Gupta, Sandeep Kumar Gupta, Yanfei Guo, Alfredo Guerreros Benavides, Elena Gyuzeleva, Christel Haenebalcke, Peter Hammerl, Ismail Hanta, Michael Hassman, Nezabravka Haytova, Yong He, Zdeněk Heralt, Laura Herpel, Felix Herth, Dante Hernández Colín, Jose Felipe Hernandez, Mitzie Hewitt, Ole Hilberg, Ulrike Himpe, Vladimir Hodzhev, Marc Höffgen, Martin Hoffmann, Teresa Hofman, Otakar Hokynar, Stanislav Holub, Sandra Hotu, Yi Hu, Kamran Hussain, Thomas Hyers, Carlos Barrera, Gabriele Illies, Yanislava Ilieva, Shiro Imokawa, Marie Grace Dawn Isidro, Gabriel Izbicki, Joshua Jacobs, Manish Jain, Soo Jang An, Jens-Ulrik Jensen, Mariola Jedrzejczak, Lukas Jerrentrup, W. Evan Johnson, Stuart Jones, Stephen Jones, Luiza Jończak, Thomas Jung, Jadwiga Kaczmarek, Thomas Kaelin, Ravi Kalhan, Veselin Kalfov, Ioannis Kalomenidis, Fusun Kalpaklioglu, Tadashi Kamei, D Karadoğan, Milan Kasl, Sandeep Katiyar, Ram S Kaulgud, Claus Keller, Steven Kelsen, Romain Kessler, Uzma Khan, William Killorn, Jae Yeol Kim, Teresa Kinyari, Mihail Kirov, Joachim Kirschner, Ivan Kiselov, Shirish Kirtane, Kamil Klenha, Vladimír Koblížek, Nadezda Kolosa, Petr Kopecký, Mariusz Korzeniowski, Pekka Koskinen, Kosta Kostov, Konstantinos Kostikas, Agata Kot, Zuzana Kovarikova, Mordechai Kramer, James Krings, Iveta Kroica, Shahrukh Kureishy, Grigor Lalov, Konstanze Landerholm, Thérèse Lapperre, Virginia Larivey, Luis Larrateguy, Samuel Lassa, Veronica Lawriwskyj, Brian Leaker, Jae Eun Lee Jae Eun Lee, Ji-Ho Lee, Ji-Hyun Lee, Kwan Ho Lee, Sang heon Lee, Sei Won Lee, Yong Chul Lee, Jiashu Li, Da-Wei Liao, Monika Lica-Górzyńska, Giuseppe Liistro, Seong-Yong Lim, Changqing Lin, Ching-Hsiung Lin, Yingxiang Lin, Muriel Lins, Krzysztof Lis, Diego Litewka, Jing Liu, Xiao Liu, Renaud Louis, Andrea Ludwig-Sengpiel, Anders Luts, Rogelio Machuca, Farah Madhani-Lovely, Cosmina Magdau, Martín Maillo, Patricia Malamud, E. Malherbe, Agata Małkiewicz, Dorota Malosek, Francois Maltais, David Manners, Eric Marchand, Adriana Marcipar, Darcy Marciniuk, Joanna Markiewicz, Charles-Hugo Marquette, Obadias Marquez, Christian Martin, Jean-Benoît Martinot, Victor Martinez Hagen, Pablo Martinez Monferran, Fernando Massola, Walter Mattarucco, Mary Matilu, Venkata Nagarjuna Maturu, Giuseppe Mazza, Andrea Medina, Lyle Melanka, Katherine Menson, Kevin Merkes, Christian Meyer, Marek Michnar, A. Milstone, Georgina Viviana Miranda Saez, Jacqueline Mirera, Ismail Mitha, Essack Mitha, Albena Mladenova, Daniela Mocanescu, Alicia Molina, Efraín Montano Gonzalez, Mohamed Mookadam, Lalaine Mortera, Robert Mróz, Muhammad Munir, Piotr Napora, Elsa Naval Sendra, Anita Naydenova, Videlis Nduba, Miroslaw Necki, Oleg Nemechkin, Sorin Nicolae, Delphine Nkuliza, Joanna Nowacka-Apiyo, Margarita Nunez, John O'Mahony, Angela Okolie, Anna Olech-Cudzik, Maria Eunice de Oliveira, Ake Olsson, Amir Onn, Robert Onder, Anna Orkwiszewska-Nalewajko, Francisco de Borja Ortega Ruiz, Juan Ortiz De Saracho Bobo, Pembe Ozunlu, Kiril Palaveev, Michael Palumbo, Anil Pandey, Vincenzo Patella, Juana Pavie Gallegos, Ilona Pavlišová, Kirsten Peacey, Bonavuth Pek, Rogelio Pendino, Liping Peng, Thierry Perez, Antonio Manuel Pérez Fernández, Eduardo Petenian, Galina Petrova, Andreia Pez, David Pham, George Philteos, Katarzyna Piatkowska, Ewa Pisarczyk-Bogacka, Hernan Piza, Szymon Placzek, Anna Polanska-Eisler, Himanshu Pophale, Elsje Louise Potgieter, L Puente-Maestu, Grażyna Pulka, Warren Ramesh, Alicia Ramirez, Kiran Rami, Murali Ramaswamy, Ricardo Ramirez Terrones, David Ramos‐Barbón, Yael Raviv, Syed Raza, Ilze Reinholde, Barbara Rewerska, Hubert Reyes, Chin Kook Rhee, Juan Antonio Riesco Miranda, Carlota Rodríguez García, Lilia Rodriguez-Ables, Jennifer Rosa, Jorge Rosas Cacho, Surita Roux, Osiris Roza, Teresa Rusicka, B Rybacka-Chabros, Abdulhassan Saad, Felipe Saavedra, Gonzalo Saenz, Pablo Sáez Scherbovsky, Allen Salm, Ronnie Samoro, Jay Sandberg, Francisco Sánchez Llamas, Piamlarp Sangsayunh, Joel Santiaguel, Mirena Sapundzhieva, Dinesh Saralaya, Simone van der Sar, Axel Schaefer, L Schaper, Florence Schleich, Christian Schlenska, Olaf Schmidt, Patricia Schonffeldt Guerrero, Thomas Schultz, Nicola Scichilone, Allan Seibert, Manas Sen, Ricardo Sepulveda Moncayo, Mohammad Shameem, Irina Shanidze, Paul Shapero, Ajeet Singh Shekhawat, Chau-Chyun Sheu, Yun Shim, Sun Hye Shin, David Shitrit, Philip Short, Farhan Siddiqui, Anna Sidorowicz-Białynicka, Jaime Signes-Costa, Thomas Siler, Absalon Rafael Silva Orellana, Kit-Man Sin, Naresh Singh, F. Sjöberg, Diana Slaveva, Elina Smilkova, Adam Śmiałowski, Kostadinka Sotirova, Roberto Sotolongo, Daniel Sousa, Clyde Southwell, Selwyn Spangenthal, Marc Spielmanns, Daniel Starobin, Heiner Steffen, Thomas Stern, G. Steven, Ana Stok, Gyöngyi Szabó, Jorge Taborda, Liangfa Tang, Yuling Tang, Hiroshi Tanaka, Tonny Tanus, Margarita Taseva, Ishak Teber, Francis Thien, Hawys Thomas, Ingrid Titlestad, Mariya Todorova, Sławomir Tokarski, Alberto Tolcachier, Stavros Tryfon, Mirosław Trzciński, Nikolaos Tzanakis, Charlotte Suppli Ulrik, Erika Unger, John Updegrove, Yacoob Vahed, Iliyana Valkanova, Carlo Vancheri, Eef Vanderhelst, Jan Willem van den Berg, Marjolein van Laren, Edwin van Velzen, Richard van Zyl-Smit, Vanko Vankov, Andrew Veale, José Velasco Garrido, Fernando Verra, Carlos Fabian Victorio, Cesar Villaran Ferreyros, Ines Vinge, Robert Voves, George Walker, Ori Wand, Chen Wang, Limin Wang, Tao Wang, Neal Warshoff, Joanna Waszkuć-Golonko, Luis Wehbe, Sabina Wehgartner-Winkler, Liping Wei, Ulla Møller Weinreich, Fuqiang Wen, Jan Westerman, Pascal Wielders, Agatha Cathrine Wilhase, Jon Torgny Wilcke, Roxana Willigs Rolon, Bin Wu, Feng Wu, Michael Wurtz, Krzysztof Wytrychowski, Pingchao Xiang, Zuke Xiao, Anahi Yanez, A Yarmolovsky, Kwang Ha Yoo, Tamer Yousef, Charles Yu, Monika Zaczek-Chmielewska, Huiqing Zeng, Li Zhao, Ziwen Zhao, Nuofu Zhang, Xiangjie Zhang, Xiangdong Zhou, Huili Zhu, Xiaoli Zhu, Yingqun Zhu, Yunkui Zhu, Nikolaos Zias, Tomasz Ziedalski, Izabela Zielińska-Leś, Maeva Zysman, Muqdad Zuriqat, Malgorzata Zurowska-Gebala · 发表于：The Lancet · 年份：2026 · DOI：10.1016/s0140-6736(26)00637-9 · 被引用次数：5 · 研究领域：Chronic Obstructive Pulmonary Disease (COPD) Research、Asthma and respiratory diseases、Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis