Dynamic Shifts in Gut Microbiota and Metabolic Pathways of Xinggao Mutton Sheep During Weaning: A Multi-Omics Analysis

作者：Xiaolong He, Jingda Yuan, Biao Wang, Qing Qin, Rigele Te, Lai Da, Xuewen Liu, Shaoyin Fu · 发表于：Animals · 年份：2026 · DOI：10.3390/ani16101532 · 研究领域：Aldose Reductase and Taurine、Gut microbiota and health、Ruminant Nutrition and Digestive Physiology

The composition and function of the intestinal microbiota of Xinggao mutton sheep were explored before and post-weaning using non-target metabolomics. Both 16S rDNA amplicon sequencing technology and serum non-target metabolomics were used to determine changes in sheep metabolites and intestinal flora. A random sampling method was used to collect fecal samples from 20 pre-weaning lambs and 20 lambs post-weaning. Analysis of the intestinal flora identified Firmicutes as the predominant phylum pre-weaning and Bacteroidota as the dominant phylum post-weaning. Joint multi-omics analysis revealed that Oscillospiraceae UCG-005 and Prevotella_9 were significantly correlated with serum L-tyrosine, Indole-3-acrylic acid, and taurine-related metabolites, suggesting their potential roles in modulating digestive health in Xinggao mutton sheep.