Long-term outcomes of a structured lifestyle-based nutritional intervention for obesity management: a 10-year observational study

作者：Мирослава Навратилова, Dagmar Seidlová, Michal Čierny, Luboš Babiak, Jana Tůmová, Luboš Bouček · 发表于：Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · 年份：2026 · DOI：10.1007/s40519-026-01852-6 · 研究领域：Bariatric Surgery and Outcomes、Diet and metabolism studies、Diabetes, Cardiovascular Risks, and Lipoproteins

BACKGROUND: Obesity is a chronic, relapsing disease associated with substantial metabolic morbidity. While bariatric surgery and pharmacotherapy can be effective, their use may be limited by invasiveness, adverse effects, cost, or long-term accessibility. There remains a need for sustainable, non-invasive lifestyle-based strategies applicable in routine outpatient care. This study evaluated 10-year outcomes of a structured lifestyle-based nutritional intervention (metabolic endolipolysis) in adults with obesity. METHODS: ) were included. The intervention was based on a defined macronutrient composition with strict dietary fat limitation (approximately 30 g/day), adequate protein intake (≥ 110 g/day), and normoglycemic carbohydrate intake, combined with behavioral support and recommended daily moderate physical activity. Body composition was assessed annually using bioelectrical impedance analysis. Metabolic outcomes included HbA1c, fasting glucose, lipid profile, and liver enzymes. RESULTS: A mean fat mass reduction of 9.6 kg was observed during the first year, with sustained reductions over the 10-year follow-up. Total fat mass decreased by 23.1%, including a 32.3% reduction in visceral fat, while lean body mass was largely preserved. Improvements were observed in metabolic parameters, including reductions in HbA1c (- 8.5%), LDL cholesterol (- 36.6%), and total cholesterol (- 30.0%). The greatest changes occurred within the first year and remained relatively stable thereafte...