Alteration of fronto-thalamic-striatal and visual network activity to positive emotional stimuli in adolescent patients with bipolar disorder during a Go/No-Go task-based functional brain MRI

作者：Xueying Wang, Jinfan Zhang, Feifei Wu, Liying Shen, Lin Wang, Han Wu, Qian Xiao, Xiaoping Yi, Xiaoqun Liu, Alessandro Grecucci, Bihong T. Chen · 发表于：NeuroImage Clinical · 年份：2026 · DOI：10.1016/j.nicl.2026.104005 · 研究领域：Bipolar Disorder and Treatment、Neural and Behavioral Psychology Studies、Schizophrenia research and treatment

BACKGROUND: Adolescent patients with bipolar disorder (BD) tend to have abnormal neural activity to emotional stimuli. This study aimed to assess alterations of neural activity within the fronto-thalamic-striatal circuit, and the fusiform gyrus during positive stimuli processing in Go/No-Go task-based brain functional MRI (fMRI). METHODS: This prospective study enrolled 43 adolescent patients with BD and 18 age- sex-matched healthy controls. All study participants underwent a task-based brain fMRI using a happy versus neutral Go/No-Go paradigm. All study participants also completed multiple affective and cognitive assessment questionnaire. RESULTS: Enhanced activity was found in the fronto-thalamic-striatal circuit including the inferior frontal gyrus and the caudate, the fusiform gyrus, the left cerebellum crus I and the hippocampus in adolescent patients with BD, during response inhibition to happy versus neutral distractors in an emotional Go/No-Go fMRI task, compared with matched healthy controls (p<0.05). Moreover, the left inferior frontal gyrus, the right fusiform gyrus and the left cerebellum crus I responses to happy versus neutral distractors were positively associated with the differences in false response errors in the patients with BD (all p<0.05, FDR corrected). The enhanced activity of the caudate nucleus and that of the right hippocampus were negatively correlated with cognitive function (all p<0.05, FDR corrected). CONCLUSION: This study found significant bra...