Mortality trends of cardiac, mediastinal and pleural malignancies in the United States, 1999–2020: a population-based analysis of demographic and geographic disparities

作者：Wenlong Ding, Fachao Shi, Siyun Li, Siwen Xue, Cunming Fang, Caoyang Fang, Caoyang Fang, Caoyang Fang · 发表于：Frontiers in Oncology · 年份：2026 · DOI：10.3389/fonc.2026.1796015 · 研究领域：Cardiac tumors and thrombi、Lung Cancer Diagnosis and Treatment、Esophageal Cancer Research and Treatment

Background: Cardiac, mediastinal, and pleural malignancies represent rare but clinically significant thoracic neoplasms. Despite their clinical importance, comprehensive epidemiological analyses of mortality trends for these tumors remain limited. This study aimed to analyze mortality trends and demographic disparities of these malignancies in the United States from 1999 to 2020. Methods: We conducted a retrospective observational study using the Centers for Disease Control and Prevention's Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) database. Adults (≥18 years) who died from cardiac, mediastinal, or pleural malignancies (ICD-10 code: C38) between January 1, 1999, and December 31, 2020, were included. Age-adjusted mortality rates (AAMRs) were calculated and stratified by sex, age, race/ethnicity, geographic region, and urbanization level. Joinpoint regression analysis was employed to identify temporal trends, with calculation of annual percent changes (APCs) and average annual percent changes (AAPCs). Results: During the study period, 5,424 deaths were attributed to cardiac, mediastinal, or pleural malignancies, with an overall AAMR of 0.109 per 100,000 population (95% CI: 0.105-0.112). Males demonstrated higher mortality rates than females (0.133 vs. 0.076 per 100,000). Elderly individuals (≥65 years) accounted for 65.08% of total deaths. Overall mortality exhibited a significant declining trend (AAPC: -4.325%; 95% CI: -4.890 to -3.191; P<0.001), charact...