18F-PSMA-1007 PET/CT in PSMA-avid bladder urothelial carcinoma with extensive bone metastases: a case report

作者：Yi-Xiang Wang, Bo Wu, Mengting Qiao, Meng Liang, Zhifang Wu · 发表于：EJNMMI Research · 年份：2026 · DOI：10.1186/s13550-026-01498-6 · 研究领域：Prostate Cancer Treatment and Research、Peptidase Inhibition and Analysis、Radiopharmaceutical Chemistry and Applications

Abstract Background: PSMA PET can accurately localize PSMA-expressing lesions. However, PSMA expression is not limited to prostate cancer cells but is also widely present in the neovascular endothelial cells of various solid tumors. Case presentation: We present a case of urothelial carcinoma of the bladder with multiple bone metastases. Conclusions: This case highlights that ¹⁸F-PSMA-1007 PET/CT improved visualization of the primary bladder lesion, and demonstrates that ¹⁸F-PSMA-1007–avid osteoblastic bone metastases can originate from bladder cancer.