[Hollow copper sulfide nanocomposites combined with photothermal and photodynamic therapy inhibits malignant behaviors of esophageal cancer cells].

作者：Pingjuan Yang, Anqi Ji, Shuxin Liao, Haonan Yao, Zhendong Gao, Pan Chen, Haoyan Cheng, Shegan Gao, Linlin Shi · 发表于：PubMed · 年份：2026 · DOI：10.12122/j.issn.1673-4254.2026.04.13 · 研究领域：Chemistry、Cancer research、Biophysics

OBJECTIVES: -based nanoparticles loaded with the photosensitizer IR780, investigate its photothermal and photodynamic (PTT-PDT) effects against esophageal cancer cells and analyze the underlying mechanisms. METHODS: was evaluated in a mouse model bearing subcutaneous esophageal cancer xenografts. RESULTS: and 808 nm laser irradiation exhibited strong synergistic PTT-PDT effects and significantly inhibited tumor growth with a good biocompatibility. CONCLUSIONS: composite nanoparticles achieve synergistic PTT-PDT antitumor activity in esophageal cancer cells which can be a promising strategy for combined therapy and targeted drug delivery for esophageal cancer.