Prognostic value of ankle‐brachial index and cardio‐ankle vascular index for mortality and cardiovascular events in older people with HIV on long‐term ART

作者：Porntep Amornritvanich, Sarawut Siwamogsatham, Pairoj Chattranukulchai, Monravee Tumkosit, Tanakorn Apornpong, Hay Mar Su Lwin, Napon Hiranburana, Yanisa Jarusyingdumrong, Win Min Han, Stephen Kerr, Anchalee Avihingsanon · 发表于：HIV Medicine · 年份：2026 · DOI：10.1111/hiv.70244 · 被引用次数：1 · 研究领域：HIV-related health complications and treatments、Peripheral Artery Disease Management、Muscle and Compartmental Disorders

OBJECTIVES: To assess the association of the Cardio-Ankle Vascular Index (CAVI) and ankle-brachial index (ABI) with all-cause mortality and major adverse cardiovascular events (MACE) in older people with HIV receiving long-term antiretroviral therapy (ART) in Thailand. METHODS: We conducted a prospective cohort study of 307 virologically suppressed participants aged ≥50 years who underwent baseline CAVI and ABI measurements. ABI was analysed both as a continuous variable and as a categorical variable using a cut-off <0.9. Outcomes were all-cause mortality and MACE (non-fatal myocardial infarction, ischaemic stroke or percutaneous coronary intervention). Associations between high CAVI (≥9) or continuous CAVI and outcomes were examined using Cox proportional hazards models adjusted for age, smoking, hypertension and interleukin-6 (IL-6). RESULTS: At baseline, 18.2% of participants had high CAVI (≥9). Over a median follow-up of 8 years, 50 participants (16.3%) experienced the composite outcome, including 37 deaths (12.1%). After adjustment, categorical CAVI ≥ 9 was significantly associated with all-cause mortality (aHR 2.67, 95% CI: 1.37-5.21, p = 0.004) but did not reach statistical significance for the composite outcome (aHR 1.64, 95% CI: 0.89-3.01, p = 0.112). However, when modelled as a continuous variable, each unit increase in CAVI was associated with an increased risk of composite outcome (aHR 1.29, 95% CI: 1.08-1.54, p = 0.004). Ever smoking, hypertension and elevated IL...