Persistent One-Year Mortality Gradient After STEMI and COVID-19: Long-Term Outcomes From the NACMI Registry

作者：Payam Dehghani, Chase J. Ellingson, Jyotpal Singh, Ellen Cravero, G.B. John Mancini, Larissa Stanberry, Mina Madan, Catherine P. Benziger, Nima Ghasemzadeh, Anna E. Bortnick, Rohan Kankaria, Cindy L. Grines, Keshav Nayak, Ehtisham Mahmud, Kevin R. Bainey, M Chadi Alraies, Akshay Bagai, Rajan A.G. Patel, Shy Amlani, Brian C. Case, Ron Waksman, Jay S. Shavadia, Jay H. Stone, Deepak Acharya, Nosheen Javed, Rodrigo Bagur, Ross Garberich, Santiago García, Timothy D. Henry · 发表于：Journal of the Society for Cardiovascular Angiography & Interventions · 年份：2026 · DOI：10.1016/j.jscai.2026.105395 · 被引用次数：1 · 研究领域：COVID-19 and healthcare impacts、COVID-19 Clinical Research Studies、Sepsis Diagnosis and Treatment

Background Patients with COVID-19 and ST-elevation myocardial infarction (STEMI) from the North American COVID-19 Myocardial Infarction (NACMI) registry had elevated in-hospital mortality compared with COVID-19-negative patients and historical controls. We examined 1-year mortality outcomes from the NACMI registry. Methods This was a substudy of NACMI centers that participated in long-term follow-up. Patients in the NACMI registry were stratified into COVID-19-positive and COVID-19-negative groups. A historical 2018-2019 control group was derived from the Midwest STEMI Consortium registry. The primary outcome was 1-year mortality. Results A total of 2358 STEMI patients (30% female) were included in this study, divided into 3 subgroups: COVID-19-positive (n = 623), COVID-19-negative (n = 694), and historical controls (n = 1041). One-year mortality in COVID-19-positive patients was 45% (HR, 4.88; 95% CI, 3.73-6.39; P < .001), compared with 27% (HR, 3.93; 95% CI, 2.92-5.29; P < .001) in COVID-19-negative patients and 11% in matched controls ( P < .001). Most deaths (86%) occurred during the index hospitalization, with a median time to death of 27 days (IQR 6, 343) in the COVID-19-positive group. Among survivors of index hospitalization, 1-year mortality was 12% (COVID-19-positive; HR, 2.20; 95% CI, 1.26-3.85; P = .006), 9.6% (COVID-19-negative; HR, 2.31; 95% CI, 1.26-4.21; P = .007), and 5.3% (controls) ( P < .001). Conclusions This study describes long-term outcomes in patients...