Chemoproteomics unveils the antibacterial mechanism of silver ions: inhibiting peptidoglycan synthesis via targeting Mur family proteins in Staphylococcus aureus

作者：Li-run Zhou, Ying Zhang, Yajian Li, Tong Yang, Zheng Chu, Qianyu Zhang, Hechen Tang, Ang Ma, Peng Gao, Chen Wang, Yin‐Kwan Wong, Cui Liu, Shengnan Shen, Junzhe Zhang, Qiaoli Shi, Huan Tang, Jigang Wang · 发表于：Chemical Science · 年份：2026 · DOI：10.1039/d6sc00255b · 被引用次数：1 · 研究领域：Antimicrobial Peptides and Activities、Antimicrobial agents and applications、Peptidase Inhibition and Analysis

exhibits a low resistance frequency compared to conventional antibiotics, underscoring its potential as an effective antimicrobial agent. Its distinct mechanism of action and reduced likelihood of resistance development indicate that it may serve not only as an effective therapeutic strategy, but also as a probe for elucidating the mechanism of bacterial peptidoglycan biosynthesis. These results offer new insights for the development of antibiotics targeting Mur family proteins.