Photoactivation of Electron Donor–Acceptor Complexes via Quinolinium Salts and 4-Carboxamide-1,4-dihydropyridines: Synthesis of N -Heteroaryl-2-carboxamides

作者：Pengpeng Yin, Kay Thwe Moe, Yun-Xuan Luo, Xiang‐Ying Tang · 发表于：Organic Letters · 年份：2026 · DOI：10.1021/acs.orglett.6c00635 · 被引用次数：1 · 研究领域：Radical Photochemical Reactions、Catalytic C–H Functionalization Methods、Oxidative Organic Chemistry Reactions

By leveraging Lewis acid coordination to increase the reduction potential of quinoline to facilitate the formation of an electron donor-acceptor (EDA) complex with Hantzsch ester donors, this work establishes a dual function of the quinolinium salts. This dual function involves the initial single-electron transfer (SET) triggering the target C-H amidation and energy transfer for the generation of singlet oxygen to mediate the subsequent oxygenation process. Consequently, this protocol achieves the transformation under mild aerobic conditions, eliminating the requirement for external photosensitizers, metal catalysts, or strong oxidants.