Hypothermic oxygenated perfusion versus standard treatment of donor hearts in heart transplantation: extended follow-up of the NIHP2019 trial

作者：Filip Rega, G L Lebreton, Marylou Para, S Michel, René Schramm, Emmanuelle Bégot, Katrien Vandendriessche, Christine Kamla, Gino Gerosa, Marius Berman, Udo Boeken, Stephen Clark, Aaron Ranasinghe, F. Ius, Alberto Forteza, Aldina Pivodic, Felix Hennig, Sabina Guenther, P. Kaul, A. Goerler, A. Aliabadi-Zuckermann, Jan Gummert, Johan Van Cleemput, Andreas Zuckermann, C Knosalla, Göran Dellgren, Andreas Wallinder · 发表于：European Heart Journal · 年份：2026 · DOI：10.1093/eurheartj/ehag264 · 被引用次数：2 · 研究领域：Transplantation: Methods and Outcomes、Mechanical Circulatory Support Devices、Cardiac Ischemia and Reperfusion

Ischaemic static cold storage (SCS) remains the standard method for preserving donor hearts before transplantation. Nevertheless, it fails to adequately prevent ischaemic injury adversely affecting post-transplant morbidity and mortality. Hypothermic oxygenated perfusion (HOPE) of the isolated donor organ before transplantation has been introduced as an alternative preservation method.1,2 In liver transplantation, comprehensive evidence concludes that HOPE reduces postoperative complications and extends the functional organ lifespan.3 The NIHP2019 trial is the first multicentre, randomized controlled study to evaluate the clinical efficacy of HOPE for donor heart preservation. Early results demonstrated a reduction in post-operative complications at 30 days for HOPE compared to static cold storage.1 This pre-specified secondary analysis of 12-month follow-up assessed whether the early benefits of HOPE translated into sustained improvements in outcome and post-transplant safety. The design and methods have been previously described.1,4 NIHP2019 (NCT03991923) is an open-label, randomized controlled trial conducted in 15 centres across 8 European countries. After randomization, adult candidates were transplanted with a donor heart preserved with either ischaemic SCS or HOPE using a portable machine perfusion system (XVIVO Perfusion, Gothenburg, Sweden). Transplant procedures and post-operative care were performed in accordance with the standard-of-care practices of the respectiv...