HIV Self-testing and Coupons Distribution by Persons Using PrEP to Create Demand for Combination HIV Prevention Services Among Men Who Have Sex With Men and Transgender Women: A Randomized Clinical Trial in the Context of the ImPrEP Project

作者：Brenda Hoagland, Thiago S. Torres, KA Konda, Ronaldo Ismério Moreira, Iuri C. Leite, Marcelo Cunha, K. Campos, Gino Calvo, Cristina Pimenta, Marcos Benedetti, Carla Rocha, Jose R. Grangeiro, Edilene Bastos, Sandro Nazer, Claudio Palombo, Mauricio de Vasconcellos, Carlos F. Caceres, Beatriz Grinzstejn, Valdilea G. Veloso · 发表于：JAIDS Journal of Acquired Immune Deficiency Syndromes · 年份：2026 · DOI：10.1097/qai.0000000000003887 · 研究领域：HIV/AIDS Research and Interventions、LGBTQ Health, Identity, and Policy、Adolescent Sexual and Reproductive Health

BACKGROUND: Despite progress in HIV treatment in Latin America, prevention efforts lag. This study assessed whether the secondary distribution of HIV self-testing (HIVST) and coupons by men who have sex with men and transgender women using preexposure prophylaxis (PrEP) is feasible and could create demand for combination HIV prevention services. SETTINGS: Substudy of the PrEP Implementation Project conducted at 2 sites in Rio de Janeiro, Brazil, and 3 sites in Lima, Peru. METHODS: A randomized controlled trial among participants using oral PrEP for at least 6 months. Participants were randomized 1:1 to receive either 5 HIVST kits with coupons or 5 coupons alone and were instructed to distribute these within their networks. Outcomes included intervention efficacy (percentage of participants recruited) and recruitment efficacy (percentage of participants who recruited at least one person). TRIAL: NCT03642314 ( clinicaltrials.gov ). RESULTS: A total of 694 participants using PrEP were enrolled: 351 (50.6%) HIVST + coupons arm and 343 (49.4%) coupons only arm. Three thousand four hundred seventy coupons were distributed, and 2472 (71.2%) were delivered for recruitment purposes. Overall, 321 individuals were recruited (Brazil: 155; Peru: 166). The coupon-only arm was more effective in recruiting individuals in Peru (21.9% vs. 12.0%, risk ratio: 0.55 [95% confidence interval: 0.41-073]) and Brazil (28.4% vs. 22.4%, risk ratio: 0.75 [95% confidence interval: 0.52-1.02]). Recruitment...