Awareness, Usage and Perceptions of Doxycycline Post‐Exposure Prophylaxis (doxyPEP) for Prevention of Sexually Transmitted Infections in Australia: Insights From a National Cross‐Sectional Survey

作者：Phyu Mon Latt, Ei T. Aung, Kate Maddaford, Kai Jonas, Christopher K. Fairley, Sarah J. Martin, Carole Khaw, Rick Varma, Caroline Thng, Manoji Gunathilake, Vincent J. Cornelisse, Haoyi Wang, Teralynn Ludwick, Ethan T. Cardwell, Michael W. Traeger, Catriona S. Bradshaw, Dash Heath‐Paynter, Benjamin Riley, Daniel Grace, Fabian Y. S. Kong, Eric P. F. Chow, the DoxyAWARE Study Group · 发表于：The Medical Journal of Australia · 年份：2026 · DOI：10.5694/mja2.70180 · 被引用次数：4 · 研究领域：Reproductive tract infections research、Syphilis Diagnosis and Treatment、Adolescent Sexual and Reproductive Health

OBJECTIVE: To examine the awareness, usage and perceptions of doxycycline post-exposure prophylaxis (doxyPEP) for sexually transmitted infection (STI) prevention among gay and bisexual men and transgender (trans) and gender diverse people in Australia. DESIGN: Cross-sectional online survey. SETTING, PARTICIPANTS: National multi-site survey in Australia from 1 July 2024 to 30 November 2024, recruiting from 13 sexual health and community clinics, 6 general practices, social media, dating applications, and university portals. Gay and bisexual men and trans and gender diverse people aged ≥ 18 years living in Australia were included in the study. MAIN OUTCOME MEASURES: DoxyPEP awareness, ever use, recent use (past 12 months), dosage regimens, sourcing methods and planned future use. RESULTS: Among 2095 participants, half (1080/2095, 51.6%) had heard of doxyPEP. Of those aware, 323/1080 (29.9%) had ever used doxyPEP, and 306/1080 (28.3%) were recent users. DoxyPEP awareness and usage varied by HIV status and pre-exposure prophylaxis (PrEP) use (p < 0.0001). Nearly two-thirds of users had taken the recommended 200 mg within 72 h after sex (205/323, 63.5%). Among recent users, 29/306 (9.5%) reported recent syphilis diagnoses, and 85/306 (27.8%) had ≥ 2 STI diagnoses in the past 12 months. Of those who had ever used doxyPEP, 135/323 (41.8%) obtained prescriptions from clinicians, 17/323 (5.3%) obtained it online, and 28/323 (8.7%) purchased it in person overseas without a prescription...