Synthesis of Carborane-Containing Flavone and Flavonol Analogues as ER Agonists and COX Inhibitors

作者：Yirong Zhang, Chenyang Ma, Linlin Wang, Yuan Li, Yuxin Lin, Zekun Yang, Changxian Yuan, Guanxiang Hao, Linlin Wang, Hui Li, Nan Sun, Zhangxiang Yin, Yong Nian, Sinan Wang · 发表于：Journal of Natural Products · 年份：2026 · DOI：10.1021/acs.jnatprod.5c01639 · 研究领域：Boron Compounds in Chemistry、Cancer, Hypoxia, and Metabolism、Radiopharmaceutical Chemistry and Applications

of 0.87 ± 0.07 μM for ERα and a selectivity of 12.8-fold toward ERβ. These compounds also showed moderate inhibitory activities toward COX-1 and COX-2.